Born in New Orleans, Louisiana, to Cuban parents, Lisette Oropesa played the flute before beginning her studies in vocal performance at Louisiana State University. She entered the Lindemann Young Artist Development Program and moved to New York City. She began her career at the Metropolitan Opera, New York, where she starred in various roles including Susanna (Le Nozze di Figaro), Manon Lescaut (Manon), Violetta (La Traviata), Nannetta (Falstaff), Gretel (Hänsel et Gretel) and Gilda (Rigoletto). She has performed Konstanze (Il Seraglio) at the Bayerische Staatsoper Munich and Vienna Staatsoper, Gilda (Rigoletto) at the Dutch National Opera, Teatro dell'opera di Roma, Los Angeles Opera, Royal Opera House Covent Garden, Metropolitan Opera de New York and Vienna Staatsoper, Norina (Don Pasquale) in Glyndebourne, the title-role of Lucia di Lammermoor at the Royal Opera House Covent Garden, the Opernhaus Zurich, Vienna Staatsoper, at the Salzburg and Aix-en-Provence festivals and at Teatro alla Scala, in Milan, and Violetta (La Traviata) at the Arena di Verona, Bayerische Staatsoper Munich, Royal Opera House Covent Garden and Teatro dell’Opera in Rome, Elvira (I Puritani) at Teatro di San Carlo in Naples, the title role of Alcina in London, Amalia (I Masnadieri) at the Bayerische Staatsoper in Munich, Fiorilla (Il turco in Italia) at Teatro Real in Madrid and Juliette (Roméo et Juliette) in Savonlinna. Her repertoire also includes Ophelie (Hamlet), Leïla (Les Pêcheurs de perles), Marie (La Fille du régiment), Rosina (The Barber of Seville) and Adina (L’Elisir d’amore). This season, she sings Marie in Chicago, Elvira in Dresden, Mathilde (Guillaume Tell) in Vienna and Amina (La sonnambula) in Rome. She won the Beverly Sills and Richard Tucker awards in 2019.

At the Paris Opera: Il Seraglio (Konstanze), 2015; Rigoletto (Gilda), 2017; Les Huguenots (Marguerite de Valois), 2018 ; L’elisir d’amore (Adina), 2018; The Barber of Seville (Rosina), 2020; Hamlet (Ophélie), 2023